About 2 years ago, I was put on the antidepressant Cymbalta. It worked wonders. I had tried pretty much every SNRI, NDRI, SSRI out there, and all mood stabilizers. Cymbalta was one of the last few. I had even had 11 sessions of ECT (shock treatments). This was the only thing that helped, coupled with Geodon (antipsychotic)... About 6 months ago, my geodon seemed to stop working as well - I would swing up too much and have psychosis symptoms. Then my Cymbalta seemed to faulter. Now it's not working at all. My pdoc put me on one of the few antipsychotics I've not tried - Clozaril. It's some heavy duty stuff. It works, but I sleep all day and have to have weekly blood tests to make sure the Clozaril doesn't make my white blood cell count bottom out. I'm suicidal again - seriously so. There are only a scant few antidepressant left to try. Even before when they both worked, I still wasn't well enough to return to school or to work - even minor stress made me break. It's been 6 years since I developed bipolar disorder. Now it's evolved into schizoaffective - bipolar + schizophrenia. Pretty much the only thing I see in my future is suicide. I'm never going to be well enough to move on with my life.