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BBC: Anti-depressants 'of little use'

theleastofthese

SF Friend
Staff Alumni
#3
It's hard for me to say conclusively that antidepressants have helped or not helped me. I'd have to be off of them for a while in order to tell if I felt worse without them, and then, a lot of my depression is situational, based on finances and other things that a drug can't help or control. So I take this article with a grain of salt, because I think that zoloft HAS helped me over the last ten years and because of all the variables that can't be accounted for in "clinical trials". Just my opinion...
 

Dreamer uk

Well-Known Member
#4
Marjorie Wallace is talking shit.

The researchers accept many people believe the drugs do work for them, but argue that could be a placebo effect - people feel better simply because they are taking a medication which they think will help them.
What a load of rubbish, the antidepressant effect is no placebo.
 

gforce7

Active Member
#5
Prozac deffinately helped me when I was first prescribed it, when I was about 16 years old. It took the edge off my depression.

Not sure if it's having much effect any more though :unsure:
 

Dreamer uk

Well-Known Member
#6
The antidepressants are definately over prescribed and there are notable side effects and withdrawal symptoms to consider.

My worry is receptor downregulation will lessen the efficacy of the antidepressant medication over time.
 
B

BOLIAO

#7
it helped me to a certaint extent. It took away the very strong suicidal urges, the hollowness / emptiness feeling, the different dimension feeling and trapped in time feeling but I'm still horribly depressed. Never believed in popping pills could help but surprisingly it did so I take them now as I realised that situational / reactional depression DOES cause chemical changes in my fucking brain. I thought I was going nuts oredi.
 

Ziggy

Antiquitie's Friend
#8
The article doesn't argue that anti-depressants are of little use for everyone. It argues that they're of little use for people with mild depression.

The researchers found that the drugs did have a positive impact on people with mild depression - but the effect was no bigger than that achieved by giving patients a sugar-coated "dummy" pill. People with severe symptoms appeared to gain more clear-cut benefit.
"Given these results, there seems little reason to prescribe anti-depressant medication to any but the most severely depressed patients, unless alternative treatments have failed to provide a benefit."
For mild depression:

Talking therapies, exercise referral and other treatments are effective for depression.
 
Last edited by a moderator:

Hae-Gi

Banned Member
#9
Once again what we've all said wasn't heard. Why don't they take us seriously :no:
Because we're "crazy" or "out of focus." Better for the psychiatrists to trust the drug companies that give them company written books on what is recommended for people with psychological problems, despite their huge incomes due to "medications" that only show that "something" happens; there's no proof that the level of serotonin, for instance (controlled with so called "SSRI's" (a company created name, by the way)), does any improvement in the mood. Much does, however, show that people often get more depressed, suicidal, or may, at times, even kill people. Despite this, the companies have managed to convince the whole world that faulty serotonin levels are a cause of depression. What it really is is just a massive social experiment.

I do, however, think that a select few may in fact be helped by some of these substances, but they are few and far between... the vast majority is just unknowingly participating in an experiment based on greed. Or, actually, all, including those who happen to get better, are participants, but the companies must of course manage to get a select few better, just by luck.
 

ToHelp

Well-Known Member
#10
"SSRI's" (a company created name, by the way
By which "company"? No, SSRI is no more than a adapted abbreviation for what this class of AD does--inhibit the reuptake of serotoin: Selective Serotonin Reuptake Inhibitors/

)), does any improvement in the mood. Much does, however, show that people often get more depressed, suicidal, or may, at times, even kill people. Despite this, the companies have managed to convince the whole world that faulty serotonin levels are a cause of depression. What it really is is just a massive social experiment.

I do, however, think that a select few may in fact be helped by some of these substances, but they are few and far between... the vast majority is just unknowingly participating in an experiment based on greed. Or, actually, all, including those who happen to get better, are participants, but the companies must of course manage to get a select few better, just by luck.[/QUOTE]
 

ToHelp

Well-Known Member
#11
"SSRI's" (a company created name, by the way
By which "company"? No, SSRI is no more than a standard adopted abbreviation for what this class of AD does--inhibit the reuptake of serotonin into the relevant neurons, thereby resulting in an articifially induced concentration in these vestibules (neurons): Selective Serotonin Reuptake Inhibitors. I'm arguing a minor point here but "SSRI" is no a for-profit company-creation than is SNRI, MAOI, or TCA.

Much does, however, show that people often get more depressed, suicidal, or may, at times, even kill people. Despite this, the companies have managed to convince the whole world that faulty serotonin levels are a cause of depression. What it really is is just a massive social experiment.
:thumbup: Yes, that first part is the epitomization of irony isn't it? And with the rest, I tend to agree.

The antidepressants are definately over prescribed and there are notable side effects and withdrawal symptoms to consider.
:thumbup: Agreed.

My worry is receptor downregulation will lessen the efficacy of the antidepressant medication over time.
Well I'm a prisoner to sertraline myself.

My abiding concern is this receptor downregulation will keep me a prisoner to the shit for life.

In any altered circumstance, the body strives for homeostasis, or a return to natural balance of its chemicals. Well, I can't seem to leave Zoloft for the LIFE of me..... maybe if I titrate over the course of a year.

The brain is extremely slow to reverse downregulation, and it's such a hazard coming off, that most people are simply resigned to stay on their AD for life.

ToHelp
 

Hae-Gi

Banned Member
#12
By which "company"? No, SSRI is no more than a standard adopted abbreviation for what this class of AD does--inhibit the reuptake of serotonin into the relevant neurons, thereby resulting in an articifially induced concentration in these vestibules (neurons): Selective Serotonin Reuptake Inhibitors. I'm arguing a minor point here but "SSRI" is no a for-profit company-creation than is SNRI, MAOI, or TCA.
Well, it is a medical company that founded the term... I'm not sure what company it was, but it probably was Pfizer. Anyway... my point was only that the term has been used by psychiatrists as a method to appear scientific in their practices, when the term, in fact, has its origin in inconclusive trials that ultimately are based on profit.
 

Bob26003

Well-Known Member
#14
Because we're "crazy" or "out of focus." Better for the psychiatrists to trust the drug companies that give them company written books on what is recommended for people with psychological problems, despite their huge incomes due to "medications" that only show that "something" happens; there's no proof that the level of serotonin, for instance (controlled with so called "SSRI's" (a company created name, by the way)), does any improvement in the mood. Much does, however, show that people often get more depressed, suicidal, or may, at times, even kill people. Despite this, the companies have managed to convince the whole world that faulty serotonin levels are a cause of depression. What it really is is just a massive social experiment.

I do, however, think that a select few may in fact be helped by some of these substances, but they are few and far between... the vast majority is just unknowingly participating in an experiment based on greed. Or, actually, all, including those who happen to get better, are participants, but the companies must of course manage to get a select few better, just by luck.

What an excellent post! Rings so true to.

I am starting to agree with the scientologists in that:

Psychiatry is a scam.

I don't think they know what the hell they are doing. Its just hit and miss.

Here take this, if that dont work, take this.

They have no clue why or how. We are all guniea pigs!
 

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