Yes. Since I've not had an abusive or otherwise bad childhood, and never had any problems getting through school until age 16, I started feeling guilty about my sudden lack of motivation (and later will to live), because I felt there should be no reason for me to feel like that. Today I struggle more than ever, and I feel like life is running away from me faster and faster.
I've just started therapy, and medication, while I consider it a last resort, is something I realise may be not only helpful, but in fact necessary for me. We are all unique individuals, but listening to people with experience and knowledge, as well as not giving up on trying to find the cause is a great thing to aim for, I think.