I've been on antidepressants which didn't work for a while though I was recently switched to bipolar medication which has not worked. Yet at the end of the day the most dominating feature of what ails me is hopelessness. I've kind of given up hope on everything. My life, the country, the world, everything. I don't really see a reason to have hope when it only ends in disappointment. Hope is the first step on the road to disappointment after all, as I have learned the hard way.