I've never found a medication that can motivate me more than my friends, family, or my own will to survive. Just my opinion.. the only meds I recommend are amphetamines, because the raw energy it can provide is enough to jump-start you at times when nothing else will. As far as anti-depressants go, mirtazapine is sometimes good when you need to sleep, but it's nothing miraculous. Meds are okay, but love from your family, peers, significant other, and yourself is the best medicine.