Is it possible to feel physically sick and just, well, 'aching' inside through depression? Sadness, emptiness, hopelessness etc are usual feelings I have every day. More and more i'm feeling kinda sick when I get really down about something. I've lost my appetite a few times which is unheard of for me in the past. I don't know what stage i'm at right now. I'm so overwhelmed with everything but completely empty in life.