Does your depression affect your GI (in terms of constipation and incontinence) , depending on how severe it is? Do you notice any difference with your GI when the depression is severe in comparison to when isn't? I am having some trouble with my GI and I want to learn whether what's going on with it is directly related to my depression, which has been severe over the past few months, and if I can solve it by switching to an antidepressant that actually does work. Lexapro is no longer effective for me, a few weeks ago I stopped taking it (I take several pills every day and the amount may be rough on the stomach lining). The rate of suicidal thoughts I've been having has dropped significantly, which is a kind of a relief. I don't feel any happier but it's nice not to be entertaining those thoughts all the time.