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Lofepramine & sore throats?!?!

Discussion in 'Therapy and Medication' started by ~Claire, Aug 26, 2008.

  1. ~Claire

    ~Claire Well-Known Member

    I have just read the leaflet that comes with your meds & it mentions that if you experience a sore throat on Lofepramine then you should contact your GP immediately.

    I've had a sore throat since I started this med & that was a good few weeks ago but the original leaflet never mentioned the sore throat bit.

    I tried to Google it but it's not really telling me anything so now I am mega confused :huh:

    Has anyone experienced a sore throat whilst on Lofepramine?

    Ta in advance :hug:
  2. kenny

    kenny Well-Known Member

    Hi Claire

    I was on Gamanil (Lofepramine) around 1994. I don't recall ever having a sore throat as such, but I do remember suffering from a very very very dry mouth and an unquenchable thirst. is it possible that the dry mouth is causing the sore throat?

    Hope that helps. am happy to talk any time, btw. Take care
  3. bhawk

    bhawk Well-Known Member

    try patient.co.uk
    my doctor told me to go on it months ago, its a great resource
  4. yanke

    yanke Active Member

    sorry i dont have much information about it but i will try and than give some information about it... THanks..
  5. yanke

    yanke Active Member

    Lomont oral suspension contains the active ingredient lofepramine, which is a type of medicine called a tricyclic antidepressant (TCA). This type of medicine acts on nerve cells in the brain. (NB. Lofepramine is also available without a brand name, ie as the generic medicine.)

    In the brain there are numerous different chemical compounds called neurotransmitters. These act as chemical messengers between the nerve cells. Serotonin and noradrenaline are neurotransmitters and they have various functions that we know of.

    When serotonin and noradrenaline are released from nerve cells in the brain they act to lighten mood. When they are reabsorbed into the nerve cells, they no longer have an effect on mood. It is thought that when depression occurs, there may be a decreased amount of serotonin and noradrenaline released from nerve cells in the brain.

    Lofepramine works by preventing serotonin and noradrenaline from being reabsorbed back into the nerve cells in the brain. This helps prolong the mood lightening effect of any released noradrenaline and serotonin. In this way, lofepramine helps relieve depression.

    It may take between two to four weeks for the benefits of this medicine to appear, so it is very important that you keep taking it, even if it doesn't seem to make much difference at first. If you feel your depression has got worse, or if you have any distressing thoughts or feelings in these first few weeks, then you should talk to your doctor.