Hi there, what is the best medication you have ever taken? As for me, surprisingly it is not a benzodiazepine but in fact and anti depressant, known as the sedating anti depressant, Mirtazapine. It helped me get out of my depression, helped me to feel alive again and also heelped me to sleep. It's a great drug and when I came off it and stayed off it the depression didn't come back. I'm not saying it is a miracle drug but it certainly helped me a lot.