A fair amount of people (apparently) are deficient in the bioactive form of Folic Acid, despite showing normal levels of Folic Acid itself. This form is called ''Methylfolate''. There are a heckload of scientific studies which demonstrate its efficacy in treatment-resistant cases: http://www.ncbi.nlm.nih.gov/pubmed/1974941 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869616/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036555/ what made me make this post was something extraordinary. I started antidepressants at 19, and started Methylfolate at 21 (it's cheap enough to buy). About a couple of months (I'm now 26), I decided to stop taking it, as I still had some bad anxiety, and thought it might be a cause.... and over the last few weeks, my whole outlook on life completely changed. I started to feel hopeless about everything (although my situation hadn't changed), decided things would not get better, and developed a suicide plan. And this was all in spite having access to so many meds! So I restarted Methylfolate a week ago, and only right about now am I finding myself slightly moving away from the edge. Do any of you guys use this at all?