Does anyone know of any disorder or trauma that may cause someone to lock themselves in their room when anyone comes to visit; even during family events. We are estimating about around the teenage years most of this was happening!! Then at a later point it happened more when he was around females that he would turn and run. I do know that he took care of his mother up to the day she died. Today we still think he has a tiny bit of fear of females, I do think it takes a long time for him to really trust them. Thank you for whatever you can help me with on this!!