I have been on sertraline for a little while. I was on 50mg, then increased to 100mg and there has been absolutely no effect whatsoever. They are increasing it to 150mg and if still no response there will be an increase to 200 mg only then will they change my meds. Has anyone started responding better at a higher dose? SSRI's have done sweet fuck all for me and I am debating whether to just stop meds altogether because I am feeling worse than I ever have done before.