Solian ???????

Discussion in 'Therapy and Medication' started by RySp123, Nov 14, 2007.

  1. RySp123

    RySp123 Guest

    Today some of my meds have been changed. One I do not seem to find info online that I can understand is the SOLIAN 400mg

    Has anyone heard of it? What is its use, for what exactly and if you know or have been on it, what is - are the side effects you have noticed?

    I am to start tomorrow on a bunch of new meds so if anyone has info, I'd appreciate knowing it today so I will be prepared for it.

    Thank you in advance.

    granny
     
    Last edited: Nov 14, 2007
  2. WhyMeWhy

    WhyMeWhy Well-Known Member

    Surely you know this:

    Amisulpride (brand-name Solian) is an antipsychotic drug sold by Sanofi-Aventis. Amisulpride is a selective dopamine antagonist. It has a high affinity for D2 (Ki 2.8 nM) and D3 (Ki 3.2 nM) dopaminergic receptors. Its dosage ranges from 200 to 1200 mg/day. Lower doses (less than 50 mg) preferentially block D2 autoreceptors that control the synthesis and release of dopamine. This results in an increase in dopaminergic transmission. This dopamine increase is hypothesized to cause a reduction in both depressive and negative symptoms. Higher doses of the drug block the postsynaptic dopamine receptors resulting in an improvement in psychoses. Its low incidence of extrapyramidal side effects (EPS) is characteristic of atypical antipsychotics.

    Amisulpride is not approved by the Food and Drug Administration for use in the United States, but it is used in Europe (France, Germany, Italy, Switzerland, the UK, ...) and Australia to treat psychoses and schizophrenia. In Italy, in 50 mg doses, it is also used as a treatment for dysthymia (under the brand name Deniban).

    In one study, anxiety measured by HAM-A total mean score decreased significantly more with amisulpride 50 mg/day (63%) than with fluoxetine 20 mg/day (54%; Pā€‰=ā€‰0.021). Another recent study concludes that amisulpride is an appropriate first-line treatment for the management of acute psychosis.

    Side effects
    Prolactin induction, nausea, weight gain, although much less than similar drugs in its class, and less commonly QT interval prolongation (which can lead to serious heart arrhythmias). Overdoses of amisulpride have been linked with torsades de pointes.
     
  3. Beret

    Beret Staff Alumni

    Ive been taking Solian for a couple of months and it has helped me greatly (dosis 400- 800mg). It has helped me not only for my psychotic symptons, but also as a mood stabilizer, even so i was also taking a mood stabilizer (Depakote). Actually it has gotten rid of most of my symptons, so its a good drug i believe. And very important for me, i havent gained any weight on it :) Feel free to pm me anytime hun.
    :hug:
    Beret xxx
     
  4. RySp123

    RySp123 Guest

    Thank you. Shall contact you in pm. :hug: