I've been on Effexor for I'd guess 3 months. The past couple weeks it seems to be actually doing it's job. I don't feel like a failure and that I'm destined to fail at everything. I've got lots of reasons to live and put up with the crap I don't like. The mistakes I made 10 years ago don't have to ruin the rest of my life. And we all eventually die anyway, so why rush it, I say. Not that I'm over suicidal thoughts, or that it's allure has left me, but I don't feel like it's my absolute destiny to die that way. Whereas before I was in the "It's just a matter of time anyway..." mode.