I'd say my current lack of and recent loss of a lot of things. Lost a girl, lost my scholarships, can't go to school, no job, no money, my friends have all up and left me, and the crushing realization that I have no marketable talents, and pretty much no real future outside of becoming a janitor and eeking out a miserable, lonely life.
Before that, it was the crushing realization that my brother was completely out of control cause he was addicted to crack at the time, my mother wasn't going to help me because she was busy sucking every other guy in town off and sleeping over their houses drunk as shit, and my friends wouldn't help me because they had their lives all sorted and they were too busy keeping it that way to help me out.