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Excessive Yawning with Trintellix

I am 5 days in to taking Trintellix for the first time and have noticed I have started to yawn excessively throughout the day. I'm not anymore tired than I normally am, but the constant yawning spells are making me drowsy.

I found an article talking about it in a patient that reported excessive yawning, and it made it seem like a rather unusual side effect. Has anyone here had this side effect? Did it go away? If this is a permanent side effect I probably shouldn't continue Trintellix since I drive a truck.


✯✯ Heart of an angel ✯✯
Staff Alumni
SF Supporter
Hey there, I looked up the side effects and yawning does not seem to be a common one.

Were any other medications changed or doses changed besides this one?

I would get in contact with your doctor 'cos its obviously something that will affect your job and sounds a bit on the dangerous side since you are a truck driver. Better to err on the side of caution.

Sometimes side effects only last when starting on or reducing doses so maybe you might not have to come off it entirely. May I ask what dose you were started on?

Wish I could help you out more but hopefully others on it will respond to this thread. Good luck.
Just an update to this, I stopped taking it. I was sick almost every night while taking Trintellix, regardless of whether or not I took it with food. On top of that and a few other side effects, it wasn't worth continuing to try it.

Legate Lanius

Well-Known Member
I was on that one, didn't help at all aside from placebo. Gave me stomach sickness. It's complete garbage (like all of the other ADs I've tried).


To Wish Impossible Things
Safety & Support
SF Supporter
It's been an absolute game changer for me after three years of trying numerous medication combos. Must admit I felt like crap for the first month or so but anti sickness meds helped a bit with that.

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