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Med crapout
- Thread starter Harmony
- Start date
Developing tolerance towards an antidepressant can be a common occurence, Harm as with potentially any other med. So that as well as those exogenous factors can be contributing towards you no longer experiencing any benefits.
Whether you need a dose change or switch, goes without saying that a med review would be in order.
Whether you need a dose change or switch, goes without saying that a med review would be in order.
Yes, I understand all that. Delving into this further, I wonder if being on antidepressants for so long has made it so I can't produce the needed neurotransmitters on my own. Some sort of overuse/rebound effect. That being said, ofc I would never abruptly discontinue or encourage anyone to avoid antidepressants. I think my next move will be the prospect of an SSNRI for the norepinephrine component because I'm certainly not at a point where I feel comfortable titrating off of an AD. That would surely be a recipe for disaster.
That is an interesting concept and definetly something to consider. I wonder if there is anything out there discussing neurochanges on prolonged AD use that can lead to this? However with the reuptake inhibitors, you're still making the neurotransmitters but just dampening down the autoinhibitory feedback mechanism. I'm thinking it could be more of tachyphylaxis situation going on.
That seems logical to step it up to an SSNRI, might as hit it with a different route. Cross-tapering method perhaps regarding the switch?
That seems logical to step it up to an SSNRI, might as hit it with a different route. Cross-tapering method perhaps regarding the switch?